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KMID : 0606320030190010061
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Journal of Phamacetical Sciences Sookmyung Women s University
2003 Volume.19 No. 1 p.61 ~ p.66
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Comparative Study on Initial Dissolution Rate of Acetaminophen Tablets
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Oh Seaung-Youl
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Abstract
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We have studied the initial dissolution kinetics of 9 marketed acetaminophen tablets in simulated gastric fluid and pH 5.8 solution, and the dissolution profiles were compared. Dissolution for the first 5 minutes from tablet J was significantly faster (p<0.01) in all sampling points than the rest of the tablets, indicating that the fast releasing component of this sustained tablet rapidly dissolves in both medium. Tablet C also showed fast dissolution, when compared to others. Considering the point that acetaminophen is a drug for antipyretic/analgesic effect and rapid dissolution can be advantageous, it seems necessary fur some tablets to be improved fur foster dissoluton.
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